New

Clinical Genomics Assistant

Broad Institute
paid time off, paid holidays, 401(k), retirement plan
United States, Massachusetts, Cambridge
Mar 19, 2026
Description & Requirements The Broad Institute of MIT and Harvard is one of the world's leading biomedical research institutes. It seeks to discover the molecular basis of major human diseases, develop effective new approaches to diagnostics and therapeutics, and disseminate discoveries, tools, methods, and data openly to the entire scientific community. Founded in 2004, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities, with collaborations spanning the globe. We are seeking motivated individuals to work in a cutting-edge environment to serve as a clinical genomics assistant jointly for the Clinical Genome Resource (ClinGen) and the Broad Clinical Laboratory LLC (BCL). ClinGen is an NIH-funded program that is building authoritative resources to define the clinical relevance of genes and variants for use in precision medicine and research (https://www.clinicalgenome.org/). BCL is a CLIA licensed, CAP accredited clinical laboratory providing physicians and physician-researchers with high quality molecular tests (https://broadclinicallabs.org/about-us/). This position would begin with training within our variant and gene-curation teams which support variant classification and gene-disease validity assessment in the clinical laboratory and ClinGen followed by supporting an array of BCL tests (including germline whole genome) and ClinGen disease-specific Expert Panel activities and affiliated projects within ClinGen and at the Broad Institute of MIT and Harvard. Principal Duties and Responsibilities: Support ClinGen curation activities Research the significance of variants and genes through literature and data review Classify variant- and gene-disease associations Support research projects that require curation of genomic knowledge Support the BCL clinical interpretation team Assist with variant and gene curation activities related to the analysis of genome data and/or test development, using existing and newly-developed analysis tools Provide project management support, including tracking of cases, communication with providers, and weekly task tracking updates Assess, maintain and improve variant annotation and filtration capabilities In addition, the CGA should possess excellent organizational skills and the ability to interact effectively with a local team at the Broad Institute and an international network of laboratories, disease experts and data sources and balance and manage multiple tasks and projects independently. The ClinGen team is part of the Translational Genomics Group (TGG, https://the-tgg.org/). The TGG supports the use of genomics in medicine, by focusing on community-centered projects that promote collaboration, data sharing and open science. The TGG is led by Heidi Rehm and consists of high-impact projects such as the Center for Mendelian Genomics co-led by Anne O'Donnell-Luria and the gnomAD project co-led by Mark Daly. The BCL team is part of the Genomics Platform and is led by Niall Lennon. This is an opportunity to play a role in large-scale genomics, informatics, and disease genetics as well as contribute to the development and implementation of transformative new clinical tests that could impact patients on an individual basis. The CGA will engage regularly with genetic counselors involved in both ClinGen and BCL activities as well as periodic networking opportunities with the wider genetic counseling community at the Broad Institute. Qualifications: Bachelor of Arts (BA) or Bachelor of Science (BS) degree in a scientific field, with a strong preference for coursework in genetics or molecular genetics Excellent written and verbal communication skills Required ability to work across our Cambridge and Burlington locations Start date: ASAP or by May or June 2026 with a minimum of a two-year commitment Job locations: 300 Binney, Cambridge, MA and 27 Blue Sky Drive, Burlington MA This role will be a hybrid position with an expectation of a minimum of 2-3 days physically in the office. The Broad Institute will not offer visa sponsorship for this opportunity. The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.