Sr Scientist II (Process and Lab Manager)

SUMMARY/JOB PURPOSE:

The Senior Scientist II (Process and Lab Manager) focuses on research using equipment in process and high potency labs (including but not limited to, HPLC, Karl Fisher, Reactarry, LC/MS, GC/MS, NMR, flow reactor, RCI, DSC, TGA, XRPD, PLM, milling equipment) to define process reaction, safety parameter, solid characterization of intermediate and final API. The Senior Scientist II will work as a process chemist to evaluate and develop IPC methods for early-stage discovery projects to facilitate a smooth scale up for supply of compounds for pre-clinical and IND enabling studies. This person will also perform tech transfers of IPC and release methods, which are developed in the lab and transferred to the internal analytical group and CDMO for clinical manufacturing. This person will also work with project teams to identify process impurities and partner with chemists to develop safe, reproducible and scalable processes.

ESSENTIAL DUTIES/RESPONSIBILITIES:

• Work with process teams to facilitate scale up of building blocks, intermediate and drug candidates.

• Maintains equipment in good working condition and troubleshoots issues.

• Manages inventory for internal intermediate and API and for CDMOs.

• Partners with chemist to evaluate and develop IPC method for early-stage discovery products. Facilitates smooth scale up for supply of compounds.

• Execute all required data using analytical and safety equipment to support in-house process development and optimization studies to facilitate scale up and transfer to CMOs.

• Collaborate with project team to source appropriate quality of starting materials.

• Prepare technical packages for transfer of processes parameter defined to internal analytical lab and CMO/CRO partner facilities.

• Keeps abreast of relevant publications and guidance documents.

SUPERVISORY RESPONSIBILITIES:

• None.

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

• Bachelor's degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Science or related field and a minimum of 9 years of relevant experience in the biotech/pharmaceutical industry; or,

• Master's degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Science or related field and a minimum of 7 years of relevant experience in the biotech/pharmaceutical industry; or,

• PhD in Organic Chemistry, Chemical Engineering, Pharmaceutical Science or related field and a minimum of 2 years of relevant experience in the biotech/pharmaceutical industry; or,

• Equivalent combination of education and experience.

Experience:

Knowledge, Skills and Abilities:

• A demonstrated track record of delivering results with high integrity, quality focus and collaboration.

• Knowledge of characterization of the physical and chemical properties of compounds of interest.

• Knowledge of process chemistry, synthetic organic chemistry, analytical methods (MS and HLPC, Karl Fisher, Reactarry, LC/MS, GC/MS, flow reactor, RCI, DSC, TGA, XRPD, PLM and milling) for physical-chemical characterization of compounds.

• Excellent interpersonal skills, oral and written communication skills.

• Excellent organizational skills, with ability to successfully manage multiple priorities.

• Ability to work effectively with cross-functional teams.

• Highly self-motivated and detail-oriented, with proven ability to work independently.

Work Environment/Physical Demands:

Our office is a modern, open-plan space that foster collaborations and creativity. Teams work closely together, sharing ideas and solutions in a supportive atmosphere. We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable workspace.

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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.