Postdoctoral Researcher

Position Description:

Postdoctoral Researcher in Structural Biology -- Medical College of Wisconsin (MCW)

The Wang Lab in the Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Postdoctoral Fellow to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques-including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy-to explore RNA structure-function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.

This position offers an exciting opportunity for candidates passionate about cutting-edge RNA biology and structural biology, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment.

Responsibilities

• Design and execute experiments to investigate the structure and dynamics of noncoding RNAs using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
• Conduct biochemical assays to study RNA-protein and RNA-small molecule interactions
• Perform in vitro transcription, RNA purification, labeling, and structural probing
• Analyze experimental data, interpret results, and contribute to manuscript preparation
• Present research findings at lab meetings, institutional seminars, and scientific conferences
• Mentor graduate students and contribute to training and scientific development within the lab
• Assist with the development of grant proposals and collaborative research initiatives

Application Instructions

Interested applicants should apply to the position and also submit the following materials to Dr. Yaqiang Wang (yawang@mcw.edu ):

• Cover letter outlining research interests and career goals
• Curriculum vitae (CV)
• Contact information for three professional references

Preferred Schedule:

Position Requirements:

Minimum Qualifications

Minimum education: Ph.D. in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular Biology, or a related discipline (or expected within 6 months of the start date)

Minimum experience: Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM). Strong background in RNA biology or nucleic acid biochemistry. Proven ability to work independently, manage time effectively, and troubleshoot experiments

Preferred Qualifications

Preferred experience: Experience with RNA preparation and purification. Familiarity with RNA structural probing methods (e.g., SHAPE, DMS mapping, RNase digestion).Experience in protein expression, purification, and RNA-protein complex reconstitution. Exposure to small-molecule screening or RNA-targeted drug discovery. Strong publication record in peer-reviewed journals

Why MCW?

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental.
• 403B Retirement Package
• Competitive Vacation, Sick Time, and Paid Holidays

MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination


The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants, or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

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